Used in conjunction with MicroBacter7 and Reef BioFuel or Katalyst, Brightwell Aquatics NeoNitro enables natural phosphorus uptake to take place in systems with inadequate nitrogen content, lowering phosphate concentration without the use of chemical filtration media and without resorting to polluting the system with organic material to raise the nitrogen content.

Successfully-operated low-nutrient and ultra-low-nutrient reef aquaria rely upon a balance of carbon, nitrogen,
and phosphorus in order to enable beneficial microbes to efficiently remove latent organic material by means of consuming it and converting it into additional microbial biomass. The resulting perpetual supply of planktonic microbes is exported from the system via protein skimming and/or captured by corals and other suspension-feeding invertebrates, recycling the once-latent organic material (waste) into additional biomass of these organisms. These nutrients are also required by zooxanthellae, and therefore by zooxanthellate invertebrates, for continued existence.
The ability of microbes to remove nutrients from their surroundings relies upon the presence of adequate supplies of organic carbon, nitrogen, and phosphorus; if any one of these nutrients is not present in adequate supply, microbial uptake slows or ceases and the concentrations of the remaining nutrients increases as nutrient input continues.

Failure to maintain adequate nutrient content in any reef system may result in bleaching and/or tissue degradation of zooxanthellate invertebrates.